Antigen compartmentation and T helper cell tolerance induction

@article{Oehen1996AntigenCA,
  title={Antigen compartmentation and T helper cell tolerance induction},
  author={Stephan Oehen and Lili Feng and Ying Jie Xia and Charles D. Surh and Stephen M Hedrick},
  journal={The Journal of Experimental Medicine},
  year={1996},
  volume={183},
  pages={2617 - 2626}
}
The process of antigen recognition depends in part on the amount of peptide antigen available and the affinity of the T cell receptor for a particular peptide-major histocompatibility complex (MHC) molecule complex. The availability of self antigen is limited by antigen processing, which is compartmentalized such that peptide antigens presented by MHC class I molecules originate in the cytoplasm, whereas peptide antigens presented by MHC class II molecules are acquired from the endocytic… CONTINUE READING

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