Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection

@inproceedings{Tamburini2014AntigenCA,
  title={Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection},
  author={Beth A Jir{\'o}n Tamburini and Matthew A. Burchill and Ross M Kedl},
  booktitle={Nature communications},
  year={2014}
}
Antigen derived from viral infections with influenza and vesicular stomatitis virus can persist after resolution of infection. Here we show that antigen can similarly persist for weeks following viral challenge and vaccination. Antigen is captured by lymphatic endothelial cells (LECs) under conditions that induce LEC proliferation. Consistent with published data showing that viral antigen persistence impacts the function of circulating memory T cells, we find that vaccine-elicited antigen… CONTINUE READING

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