Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation.

@article{Keck2014AntigenAA,
  title={Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation.},
  author={Simone Keck and Mathias Schmaler and Stefan Ganter and Lena Wyss and Susanne G. Oberle and Eric S. Huseby and Dietmar Zehn and Carolyn G King},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 41},
  pages={14852-7}
}
Cumulative T-cell receptor signal strength and ensuing T-cell responses are affected by both antigen affinity and antigen dose. Here we examined the distinct contributions of these parameters to CD4 T-cell differentiation during infection. We found that high antigen affinity positively correlates with T helper (Th)1 differentiation at both high and low doses of antigen. In contrast, follicular helper T cell (TFH) effectors are generated after priming with high, intermediate, and low affinity… CONTINUE READING
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