Antigen Specificity of Human TCR Cells

T cells expressing the TCR constitute a small fraction of T cells in circulating blood whereas they are abundant in some peripheral lymphoid organs and mucosal sites. The TCR V 9/V 2 heterodimer is expressed on a large fraction of human TCR cells. This receptor is activated by endogenous and bacterial phosphorylated metabolites, which accumulate in tumour… (More)