Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells

@inproceedings{Koido2010AntigenSpecificPC,
  title={Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells},
  author={Shigeo Koido and Sadamu Homma and Eiichi Hara and Yoshihisa Namiki and Toshifumi Ohkusa and Jianlin Gong and Hisao Tajiri},
  booktitle={Journal of biomedicine & biotechnology},
  year={2010}
}
The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses. Thus, DCs-based vaccination represents a potentially powerful strategy for induction of antigen-specific CTLs. Fusions of DCs and whole tumor cells represent an alternative approach to deliver, process, and subsequently present a… CONTINUE READING

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