Antigen-Specific FoxP 3-Transduced T-Cells Can Control Established Type 1 Diabetes

@inproceedings{Jaeckel2005AntigenSpecificF3,
  title={Antigen-Specific FoxP 3-Transduced T-Cells Can Control Established Type 1 Diabetes},
  author={Elmar Jaeckel and Harald von Boehmer and Michael P. Manns},
  year={2005}
}
CD4 CD25 T-cells can be used to interfere with spontaneous autoimmune diseases such as type 1 diabetes. However, their low frequency and often unknown specificity represent major obstacles to their therapeutic use. Here we have explored the fact that ectopic expression of the transcription factor Foxp3 can confer a suppressor phenotype to naı̈ve CD4 T-cells. We found that retroviral transduction of polyclonal CD4 T-cells with FoxP3 was not effective in interfering with established type 1… CONTINUE READING
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