Antigen Recognition Responsible for the Induction In Vitro of the Secondary Response

@article{Mitchison1967AntigenRR,
  title={Antigen Recognition Responsible for the Induction In Vitro of the Secondary Response},
  author={Neil Mitchison},
  journal={Cold Spring Harbor Symposia on Quantitative Biology},
  year={1967},
  volume={32},
  pages={431-439}
}
  • N. Mitchison
  • Published 1967
  • Medicine
  • Cold Spring Harbor Symposia on Quantitative Biology
Quantitative analysis of antigen-mediated CD4 T cell - CD4 T cell cooperation determining the Th1/Th2 phenotype of a primary immune response
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The Continuing Carrier Problem
TLDR
It is clear that: 1) immunoglobulins are heterogeneous in their capacity to bind molecular patterns (antigens) foreign to the body, 2) lymphocytes bind antigens with the aid of surface receptor molecules, and 3) specificity is determined prior to antigen contact.
DEMONSTRATION OF HEAVY AND LIGHT CHAIN ANTIGENIC DETERMINANTS ON THE CELL-BOUND RECEPTOR FOR ANTIGEN
TLDR
High-rate antibody-forming cells and immunological memory cells can be selectively retained if filtered through a column coated with relevant antigen, andCriss-cross studies using antisera specific for gamma 1 or gamma 2a heavy chains showed that the membrane receptor has the same heavy chain as will be present in the eventual product of that cell, the humoral antibody.
HAPTEN-CARRIER RELATIONSHIPS OF ISOANTIGENS
TLDR
In chickens, erythrocyte isoantigens have hapten-carrier relationships and it is postulated that every humoral antibody response involves the cooperation of a carrier with a haptes and the progressive conversion by antibody of haptens to carriers.
The history of the two‐signal model of lymphocyte activation: A personal perspective
TLDR
The two signal model has not only provided a substantiated framework for understanding how antigen interacts differently with B cells and CD8 T cells, to result in their inactivation and activation, but its postulates are pertinent to contemporary issues concerning the in activation and activation of CD4 T cells.
Management of Subtrochanteric Proximal Femur Fractures: A Review of Recent Literature
TLDR
The purpose of this paper is to examine the recent literature on the epidemiology, classification, initial evaluation, and definitely treatment for subtrochanteric femur fractures to assist the physician to determine the optimal treatment strategy and avoid potential surgical complication.
Thymus-Derived Rat Lymphocyte Recepto Nonserologically Defined Product of the 1 Histocompatibility Gene Complex
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The results suggest that the thymus-derived lymphocyte receptor for cell-surface aintigens is a product of the rat major hlisto- compatibility locus, which is not identical withi the serologically defined anitigells.
The Carrier Effect and T Cell/B Cell Cooperation in the Antibody Response
  • D. Parker
  • Biology
    The Journal of Immunology
  • 2013
This month’s Pillars of Immunology papers by Av Mitchison ([1][1], [2][2]) from 1971 provided extensive evidence for an emerging consensus on the role of cellular cooperation in the Ab response. The
Years in Cologne.
TLDR
The Immunology Department became a place, and little universe in itself, where young scientists from all over the world came together to study cellular and molecular mechanisms of antibody formation, which included work on normal and malignant B cells in the human, particularly the origin of Hodgkin lymphoma.
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