Antigen Presentation: Kissing cousins exchange CLIP

  title={Antigen Presentation: Kissing cousins exchange CLIP},
  author={Frances Sanderson and John Trowsdale},
  journal={Current Biology},
A central event in the development of a specific immune response is recognition by the T-cell receptor of an antigenic peptide bound within the groove of a class I or class II molecule of the major histocompatibility complex (MHC) [1]. Class I molecules handle peptides from proteins synthesized within the cell, such as viral proteins, which they present to lymphocytes bearing the cell-surface marker CD8. Class I-binding peptides are generated by a multi-component protease, the proteasome, and… CONTINUE READING


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