Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.

Abstract

Transgenic mice expressing a T cell receptor heterodimer specific for a fragment of pigeon cytochrome c plus an MHC class II molecule (I-Ek) have been made. We find that H-2k alpha beta transgenic mice have an overall increase in the number of T cells and express a 10-fold higher fraction of cytochrome c-reactive cells than H-2b mice. Surface staining of… (More)

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Cite this paper

@article{Berg1989AntigenMHCspecificTC, title={Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.}, author={Leslie J Berg and Andrew Mark Pullen and Barbara Fazekas de St Groth and Diane J. Mathis and Christophe Benoist and Mark M. Davis}, journal={Cell}, year={1989}, volume={58 6}, pages={1035-46} }