Antigen Export during Liver Infection of the Malaria Parasite Augments Protective Immunity

@inproceedings{Montagna2014AntigenED,
  title={Antigen Export during Liver Infection of the Malaria Parasite Augments Protective Immunity},
  author={Georgina N Montagna and Macarena Beigier-Bompadre and Martina Becker and Richard A. Kroczek and Stefan H. E. Kaufmann and Kai Matuschewski},
  booktitle={mBio},
  year={2014}
}
Protective immunity against preerythrocytic malaria parasite infection is difficult to achieve. Intracellular Plasmodium parasites likely minimize antigen presentation by surface-expressed major histocompatibility complex class I (MHC-I) molecules on infected cells, yet they actively remodel their host cells by export of parasite factors. Whether exported liver-stage proteins constitute better candidates for MHC-I antigen presentation to CD8(+) T lymphocytes remains unknown. Here, we… CONTINUE READING
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