Antifungal triterpene glycosides from the sea cucumber Holothuria (Microthele) axiloga.

@article{Yuan2009AntifungalTG,
  title={Antifungal triterpene glycosides from the sea cucumber Holothuria (Microthele) axiloga.},
  author={Wei-Hua Yuan and Yang-hua Yi and Ren-Xiang Tan and Zeng-lei Wang and Guoquan Sun and Mei Xue and Hongwei Zhang and Hai-Feng Tang},
  journal={Planta medica},
  year={2009},
  volume={75 6},
  pages={
          647-53
        }
}
Three new holostan-type triterpene glycosides, arguside F (1), impatienside B (2), and pervicoside D (3), together with a known saponin, holothurin B ( 4) were isolated from the sea cucumber Holothuria (Microthele) axiloga H. L. Clark. On the basis of spectroscopic data and chemical reactions, the structures of the new compounds were elucidated. Compound 2 showed significant antifungal activities against six strains (1 < or = MIC(80) < or = 4 microg/mL). The stereochemistry of holothurin B (4… 

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References

SHOWING 1-10 OF 10 REFERENCES

Arguside A: A New Cytotoxic Triterpene Glycoside from the Sea Cucumber Bohadschia argus Jaeger

A new holostane‐based triterpene glycoside, arguside A (1), was isolated from the sea cucumber Bohadschia argus, collected in the South China Sea and exhibited significant cytotoxicity against different human tumor cell lines.

Two new holostan-type triterpene glycosides from the sea cucumber Bohadschia marmorata JAEGER.

Two new holostan-type triterpene glycosides were isolated from the sea cucumber Bohadschia marmorata JAEGER and showed considerable antifungal activities against six strains.

A New Cytotoxic Lanostane‐Type Triterpene Glycoside from the Sea Cucumber Holothuria impatiens

The two glycosides were found to exhibit in vitro cytotoxicities similar to or better than those of the potent anticancer drug etoposide against seven different human tumor cells, with IC50 values of 0.37–2.75 μg/ml.

Marine natural products. XVIII. Four lanostane-type triterpene oligoglycosides, bivittosides A, B, C, and D, from the Okinawan sea cucumber Bohadschia bivittata Mitsukuri.

A full account of the structure elucidation of four lanostane-type triterpene oligoglycosides, bivittosides A(6), B(8), C(9), and D (10), is presented. Bivittosides were isolated from body-walls and

Marine Natural Products. XIX. : Pervicosides A, B, and C, Lanostane-Type Triterpene-Oligoglycoside Sulfates from the Sea Cucumber Holothuria pervicax

Triterpene-oligoglycoside constituents, contained in the body walls and the Cuvierian tubules f the sea cucumber Holothuria pervicax (torafu-namako in Japanese), were investigated and purified in

Marine natural products. XIV. Structures of echinosides A and B, antifungal lanostane-oligosides from the sea cucumber Actinopyga echinites (Jaeger).

Two antifungal lanostane-type triterpene oligosides were isolated from the sea cucumber Actinopyga echinites collected in Okinawa Prefecture and the structures of echinosides A and B have been elucidated respectively.

[Carbon 13 NMR spectroscopy].

This new edition has been completely revised to take into account new techniques and the increased use of computers, including those for multiplicity analysis and two-dimensional homo- or hetero-nuclear shift correlations.