Antifungal mechanism of polygodial.

  title={Antifungal mechanism of polygodial.},
  author={Isao Kubo and Ken-Ichi Fujita and Sang Han Lee},
  journal={Journal of agricultural and food chemistry},
  volume={49 3},
The primary antifungal action of polygodial comes in part from its ability to function as a nonionic surfactant, disrupting the lipid-protein interface of integral proteins and denaturing their conformation. As a result, the antifungal mechanism of this sesquiterpene dialdehyde is associated with the membrane functions or derangement of the membrane. For example, the glucose-induced medium acidification process of Saccharomyces cerevisiae was inhibited by polygodial, presumably caused by… CONTINUE READING

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