Antifungal macrocyclic polylactones from Penicillium verruculosum.

  title={Antifungal macrocyclic polylactones from Penicillium verruculosum.},
  author={Jens Breinholt and Gorm Jensen and R. B. Nielsen and Carl Erik Olsen and Jens C Frisvad},
  journal={The Journal of antibiotics},
  volume={46 7},
Three macrocyclic polylactones have been isolated from Penicillium verruculosum. Two were found to be novel and the third to be identical with NG-012(1). Their structures were elucidated by spectroscopic and chemical methods. A full assignment of 1H- and 13C-resonances in acetone-d6 are given for all three compounds. The compounds show antifungal activity.