Antifungal drug resistance evokedvia RNAi-dependent epimutations

  title={Antifungal drug resistance evokedvia RNAi-dependent epimutations},
  author={Silvia Calo and Cecelia Shertz-Wall and Soo Chan Lee and Robert J. Bastidas and Francisco E Nicol{\'a}s and Joshua A. Granek and Piotr A. Mieczkowski and Santiago R. Torres-Martinez and Rosa M Ruiz-Vazquez and Maria Elena Cardenas and Joseph Heitman},
Microorganisms evolve via a range of mechanisms that may include or involve sexual/parasexual reproduction, mutators, aneuploidy, Hsp90 and even prions. Mechanisms that may seem detrimental can be repurposed to generate diversity. Here we show that the human fungal pathogen Mucor circinelloides develops spontaneous resistance to the antifungal drug FK506 (tacrolimus) via two distinct mechanisms. One involves Mendelian mutations that confer stable drug resistance; the other occurs via an… CONTINUE READING
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