Antifungal curcumin promotes chitin accumulation associated with decreased virulence of Sporothrix schenckii.

@article{Huang2016AntifungalCP,
  title={Antifungal curcumin promotes chitin accumulation associated with decreased virulence of Sporothrix schenckii.},
  author={Lilin Huang and J. Zhang and Tianzhang Song and Liyan Yuan and Junjie Zhou and Hongling Yin and Tailong He and W. Gao and Y. Sun and X. Hu and Huaiqiu Huang},
  journal={International immunopharmacology},
  year={2016},
  volume={34},
  pages={
          263-270
        }
}
  • Lilin Huang, J. Zhang, +8 authors Huaiqiu Huang
  • Published 2016
  • Biology, Medicine
  • International immunopharmacology
  • Curcumin, a yellow polyphenol compound, is known to possess antifungal activity for a range of pathogenic fungi. However, the fungicidal mechanism of curcumin (CUR) has not been identified. We have occasionally found that chitin redistributes to the cell wall outer layer of Sporothrix schenckii (S. schenckii) upon sublethal CUR treatment. Whether CUR can affect chitin synthesis via the protein kinase C (PKC) signaling pathway has not been investigated. This study describes a direct fungicidal… CONTINUE READING
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