Antifungal curcumin induces reactive oxygen species and triggers an early apoptosis but prevents hyphae development by targeting the global repressor TUP1 in Candida albicans.

@article{Sharma2010AntifungalCI,
  title={Antifungal curcumin induces reactive oxygen species and triggers an early apoptosis but prevents hyphae development by targeting the global repressor TUP1 in Candida albicans.},
  author={Monika Sharma and R. Manoharlal and N. Puri and R. Prasad},
  journal={Bioscience reports},
  year={2010},
  volume={30 6},
  pages={
          391-404
        }
}
  • Monika Sharma, R. Manoharlal, +1 author R. Prasad
  • Published 2010
  • Biology, Medicine
  • Bioscience reports
  • In the present study, we have investigated the antifungal effects of a natural polyphenol, CUR (curcumin), against albicans and non-albicans species of Candida and have shown its ability to inhibit the growth of all the tested strains. The inhibitory effects of CUR were independent of the status of the multidrug efflux pump proteins belonging to either ABC transporter (ATP-binding cassette transporter) or MFS (major facilitator) superfamilies of transporters. By using a systemic murine model of… CONTINUE READING
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