Antifungal compounds with anticancer potential from Trichoderma sp. P8BDA1F1, an endophytic fungus from Begonia venosa.

@article{Grigoletto2020AntifungalCW,
  title={Antifungal compounds with anticancer potential from Trichoderma sp. P8BDA1F1, an endophytic fungus from Begonia venosa.},
  author={Diana Fortkamp Grigoletto and Daniela Barretto Barbosa Trivella and Andr{\'e} Gustavo Tempone and Andr{\'e} Rodrigues and Ana Maria Lima Correia and Simone P Lira},
  journal={Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]},
  year={2020}
}
Fungi in the genus Trichoderma are notorious producers of secondary metabolites with diverse applications, such as antibacterial, antifungal, and plant growth-promoting properties. Peptaibols are linear peptides produced by such fungi, with more than 440 compounds described to date, including tricholongins, longibrachins, trichobrachins, and trichovirins. Peptaibols are synthesized by non-ribosomal peptide synthetases and they have several biological activities. Our research group isolated four… 
Fungal Guttation, a Source of Bioactive Compounds, and Its Ecological Role—A Review
TLDR
The metabolites present in fungal exudates, their diversity, and bioactivities are described, Pointing to the significance of fungal ecology and natural products discovery, selected aspects of guttation in the fungi are discussed.
Peptaibols as Potential Antifungal and Anticancer Antibiotics: Current and Foreseeable Development (Review)
TLDR
Today’s knowledge on the sources, direct surface applications, and the mode of action of the peptaibols with anticancer and antifungal activity produced by filamentous fungi is summarized.
Mass Spectrometry-Based Technology and Workflows for Studying the Chemistry of Fungal Endophyte Derived Bioactive Compounds.
TLDR
The mass spectrometry (MS)-based approach, being highly sensitive, reproducible, and reliable, produces quick and high-profile identification and quantification of fungal endophyte derived bioactive compounds.
Fungal Secondary Metabolites as Inhibitors of the Ubiquitin–Proteasome System
  • M. Staszczak
  • International Journal of Molecular Sciences
  • 2021
The ubiquitin–proteasome system (UPS) is the major non-lysosomal pathway responsible for regulated degradation of intracellular proteins in eukaryotes. As the principal proteolytic pathway in the

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Structural Diversity and Bioactivities of Peptaibol Compounds From the Longibrachiatum Clade of the Filamentous Fungal Genus Trichoderma
This study examined the structural diversity and bioactivity of peptaibol compounds produced by species from the phylogenetically separated Longibrachiatum Clade of the filamentous fungal genus
Trichoderma: Biodiversity, Ecological Significances, and Industrial Applications
TLDR
Based on the phylogenetic study, several researchers reported that Trichoderma and Hypocrea form a single holomorph genus, within which two major clades can be distinguished.
Antiprotozoan activity of Brazilian marine cnidarian extracts and of a modified steroid from the octocoral Carijoa riisei
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The results indicate the potential of cnidarian natural compounds as antileishmanial drug candidates, and a modified steroid isolated from the octocoral Carijoa riisei is evaluated.
New Trichobrachins, 11-residue peptaibols from a marine strain of Trichoderma longibrachiatum
TLDR
A marine strain of Trichoderma longibrachiatum isolated from blue mussels (Mytilus edulis) was investigated for short peptaibol production and there was an exponential relation between their relative hydrophobicity and their cytotoxicity on KB cells.
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TLDR
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TLDR
Two nonadecapeptides, tricholongins BI and BII, which display antifungal and antibacterial activities, have been isolated from in vitro cultures of the fungus Trichoderma longibrachiatum and the results suggest that the N-terminus contains mixed alpha/3(10) bonds.
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TLDR
Monitoring production and degradation of peptaibiotics in a pilot experiment revealed that the biosynthesis of TB II and TB III peptides starts two days after the beginning of fermentation, which unequivocally demonstrates that those two 18‐residue TB I and TB II peptides with the free carboxy terminus result from enzymatic C‐terminal degradation of the 20‐resido peptides.
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TLDR
Owing to the ubiquity and biodiversity of the fungal producers in the biosphere, the discovery of a myriad of peptaibiotics within the next decade is predicted.
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TLDR
The antimicrobial and membrane-perturbing properties of longibrachins, which are described here for the first time, were shown to be correlated.
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TLDR
The data support the use of hyporientalin A as a promising new and efficient antifungal drug in the treatment of candidiasis while controlling toxicity.
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