Antifungal clerodane diterpenes from Macaranga monandra (L) Muell. et Arg. (Euphorbiaceae).

  title={Antifungal clerodane diterpenes from Macaranga monandra (L) Muell. et Arg. (Euphorbiaceae).},
  author={M. A. Salah and E. Bedir and N. Toyang and I. Khan and M. D. Harries and D. E. Wedge},
  journal={Journal of agricultural and food chemistry},
  volume={51 26},
  • M. A. Salah, E. Bedir, +3 authors D. E. Wedge
  • Published 2003
  • Biology, Medicine
  • Journal of agricultural and food chemistry
  • Hexane and ethyl acetate phases of the methanol extract of Macaranga monandra showed fungal growth inhibition of Colletotrichum acutatum, C. fragariae and C. gloeosporioides, Fusarium oxysporum, Botrytis cinerea, Phomopsis obscurans, and P. viticola. Bioassay-guided fractionation led to the isolation of two active clerodane-type diterpenes that were elucidated by spectroscopic methods (1D-, 2D-NMR, and MS) as kolavenic acid and 2-oxo-kolavenic acid. A 96-well microbioassay revealed that… CONTINUE READING
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