Antifungal and Antibacterial Activity of the Newly Synthesized 2‐Xanthone Derivatives

@article{Marona2009AntifungalAA,
  title={Antifungal and Antibacterial Activity of the Newly Synthesized 2‐Xanthone Derivatives},
  author={H. Marona and N. Szkaradek and E. Karczewska and D. Trojanowska and A. Budak and P. Bober and Waldemar Przepi{\'o}rka and M. Cegła and E. Szneler},
  journal={Archiv der Pharmazie},
  year={2009},
  volume={342}
}
A series of 2‐substituted xanthone derivatives 8–20 containing selected allyl, cinnamyl, morpholine, and imidazole moieties were synthesized and tested for their antifungal and antibacterial in‐vitro properties. Of the newly synthesized derivatives, ten revealed antifungal activity especially against Trichophyton mentagrophytes (the biggest inhibition zones ranged 35 mm for 11 and 13). 2‐(3‐(Allylamino)propoxy)‐9H‐xanthen‐9‐one hydrochloride 9 inhibited growth of all of the examined fungal… Expand
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References

SHOWING 1-10 OF 32 REFERENCES
Synthesis and Antibacterial Activity of Quinolone‐Based Compounds Containing a Coumarin Moiety
TLDR
Generally, in both gram‐positive and gram‐negative bacteria, better results are obtained with cyclopropyl at the N‐1 position of the quinolone ring and 2‐oxo‐ on the ethyl spacer of coumarin and piperazine rings. Expand
(2-Arylhydrazonomethyl)-substituted xanthones as antimycotics: synthesis and fungistatic activity against Candida species.
A series of arylhydrazones derived from various 6,8-diacetoxy- or 6,8-dihydroxy-9-oxo-9H-xanthene carboxaldehydes were synthesized and evaluated for their in vitro antifungal properties against twoExpand
Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species.
TLDR
Bioassay-guided fractionation resulted in the isolation of four antifungal agents from the roots of Cudrania cochinchinensis, including cudraxanthone S, cudraflavanone B, and toxyloxanthone C and wighteone. Expand
Substituted Xanthones as Antimycobacterial Agents, Part 2: Antimycobacterial Activity
TLDR
The semiquantitative evaluation of activity against the different strains of mycobacteria resulted in a classification into three activity classes, which will be used as dependent parameter in QSAR investigations, to be published in Part 3 of this series. Expand
Antibacterial activity of crude extracts from Mexican medicinal plants and purified coumarins and xanthones.
TLDR
Thirty-two extracts from 22 Mexican medicinal plants of 15 different families were assayed to determine their antibacterial activity against Escherichia coli and Staphylococcus aureus, and Coumarins and xanthones were isolated as the principle compounds from the last two plants. Expand
Antitumor effect of 2,6-di(2,3-epoxypropoxy)xanthone on tumor cell lines.
TLDR
The data suggest that the EPX-mediated inhibition of cell proliferative capacity of 212 and T24 cells was preceded by a selective down-regulation of Ha-ras oncogene RNA levels, which indicates that EPX probably suppresses tumor cell proliferation by inhibiting DNA synthesis and reverses the transformed properties by suppressing Ha-rans gene expression. Expand
Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo.
TLDR
5-Methylxanthenone-4-acetic acids has a similar level of activity to that of flavoneacetic acid in the test systems employed but is more than 7-fold as dose potent, with 5-substituted compounds being clearly the most dose potent. Expand
Synthesis and Evaluation of Some Xanthone Derivatives for Anti‐Arrhythmic, Hypotensive Properties and Their Affinity for Adrenergic Receptors
TLDR
Binding studies are in agreement with the pharmacological results and could explain anti‐arrhythmic effect of compound 15 and anti-arrhythmmic and hypotensive effects of compounds 9 and 12. Expand
Flavone and xanthone derivatives related to fluoroquinolones.
A number of flavone and xanthone derivatives bearing some characteristic features of fluoroquinolones such as the fluorine atom and an ortho piperazine ring are described. The new compounds have beenExpand
Allylamine Type Xanthone Antimycotics
TLDR
A number of xanthone derivatives bearing the basic chain of naftifine and butenafine antimycotics in 1, 2, 3, and 4 nuclear positions show significant activity against, Cryptococcus neoformans and the regioisomer 4d. Expand
...
1
2
3
4
...