Antifungal agents and liver toxicity: a complex interaction.

  title={Antifungal agents and liver toxicity: a complex interaction.},
  author={Frank P Tverdek and Diamantis P Kofteridis and Dimitrios P Kontoyiannis},
  journal={Expert review of anti-infective therapy},
  volume={14 8},
INTRODUCTION The number of antifungal agents has sharply increased in recent decades. Antifungals differ in their spectrum of activity, pharmacokinetic/pharmacodynamic properties, dosing, safety-profiles and costs. Risk of developing antifungal associated hepatotoxicity is multifactorial and is influenced by pre-existing liver disease, chemical properties of the drug, patient demographics, comorbidities, drug-drug interactions, environmental and genetic factors. Antifungal related liver injury… CONTINUE READING
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