Antifungal activity of murine polymorphonuclear neutrophils against Histoplasma capsulatum.

@article{Kurita1991AntifungalAO,
  title={Antifungal activity of murine polymorphonuclear neutrophils against Histoplasma capsulatum.},
  author={Nobuyuki Kurita and Elmer Brummer and Souichi Yoshida and Kazuko Nishimura and Makoto Miyaji},
  journal={Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology},
  year={1991},
  volume={29 3},
  pages={133-43}
}
Murine polymorphonuclear neutrophils (PMN) were examined for fungicidal and fungistatic activity against yeast cells of Histoplasma capsulatum. In a 16-h limiting dilution assay (LDA) (constant number of PMN versus decreasing numbers of yeast cells) where PMN to yeast cell ratios were high (0.4-1.5 x 10(5):1), murine PMN exhibited a limited fungicidal effect on H. capsulatum as measured by sterilization of cultures containing one to four yeast cells. On the other hand, inoculum colony forming… CONTINUE READING