Antifungal activity of a human antiglucuronoxylomannan antibody.

@article{Zhong1998AntifungalAO,
  title={Antifungal activity of a human antiglucuronoxylomannan antibody.},
  author={Zhaojing Zhong and Liise-anne Pirofski},
  journal={Clinical and diagnostic laboratory immunology},
  year={1998},
  volume={5 1},
  pages={58-64}
}
The human immunoglobulin M (IgM) monoclonal antibody (MAb) 2E9 binds the glucuronoxylomannan (GXM) of Cryptococcus neoformans serotypes A, B, and D. This study was undertaken to determine the opsonic efficacy of 2E9 and its ability to promote the antifungal activity of human polymorphonuclear neutrophils (PMNs) against C. neoformans. We incubated purified PMNs with fluorescein isothiocyanate-labeled C. neoformans cells that were treated with the GXM IgM 2E9, IgM antibodies that do not bind GXM… CONTINUE READING

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These findings strongly suggest that antibody - mediated deposition of complement components on the cryptococcal capsule can augment PMN complement receptor - mediated antifungal activity .
Our data demonstrate that the human GXM IgM 2E9 can mediate PMN phagocytosis and C. neoformans growth inhibition in vitro .
Our data demonstrate that the human GXM IgM 2E9 can mediate PMN phagocytosis and C. neoformans growth inhibition in vitro .
These findings strongly suggest that antibody - mediated deposition of complement components on the cryptococcal capsule can augment PMN complement receptor - mediated antifungal activity .
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