Antifungal activity of a Candida albicans GGTase I inhibitor-alanine conjugate. Inhibition of Rho1p prenylation in C. albicans.

@article{Murthi2003AntifungalAO,
  title={Antifungal activity of a Candida albicans GGTase I inhibitor-alanine conjugate. Inhibition of Rho1p prenylation in C. albicans.},
  author={K. Murthi and Susan E. Smith and A. Kluge and G. Bergnes and P. Bureau and V. Berlin},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2003},
  volume={13 11},
  pages={
          1935-7
        }
}
An alanine conjugate of a Candida albicans geranylgeranyl transferase I inhibitor was synthesized to facilitate its uptake into the fungal cell. The antifungal activity of CaGGTase-Ala conjugate is demonstrated. It is also shown that the CaGGTase-Ala conjugate affects prenylation of endogenous Rho1p, but has no effect on prenylation of endogenous Ras1p. 
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