Antifungal activity of C3a and C3a-derived peptides against Candida.

@article{Sonesson2007AntifungalAO,
  title={Antifungal activity of C3a and C3a-derived peptides against Candida.},
  author={A Sonesson and Lovisa Ringstad and Emma Andersson Nordahl and Martin Malmsten and Matthias M{\"o}rgelin and Artur Schmidtchen},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1768 2},
  pages={346-53}
}
Antimicrobial peptides are generated during activation of the complement system [Nordahl et al. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:16879-16884]. Here we show that the anaphylatoxin C3a exerts antimicrobial effects against the yeast Candida. Fluorescence microscopy and electron microscopy analysis demonstrated that C3a-derived peptides bound to the cell surface of Candida, and induced membrane perturbations and release of extracellular material. Various Candida isolates were found to… CONTINUE READING