Antifungal Peptide Modeling, Folding and Mimetic Design

  title={Antifungal Peptide Modeling, Folding and Mimetic Design},
  author={Shoeib Moradi},
The antifungal peptides represent diverse structures for drug design. Unfortunately, they provide inferior drug candidates because of their low oral bioavailability, potential immunogenicity, poor in vivo metabolic stability and high molecular weight. Recent efforts have focused on the creation of non-natural peptide mimetics. Their artificial backbone makes most peptidomimetics resistant to degradative enzymes, thus, increasing the stability of peptidomimetic drugs in the body. In the present… CONTINUE READING