Antifolates targeted specifically to the folate receptor.

  title={Antifolates targeted specifically to the folate receptor.},
  author={Ann L. Jackman and Davinder Singh Theti and David D. Gibbs},
  journal={Advanced drug delivery reviews},
  volume={56 8},
Most antifolate drugs are efficiently transported by the reduced-folate carrier (RFC). However, several also bind with high affinity to the alpha-isoform of the folate receptor (alpha-FR) and there is evidence to suggest that this transport mechanism may contribute to their activity when the receptor is highly overexpressed or when the extracellular folate concentration is very low. In particular, the presence of the alpha-FR on tumour cell lines sensitises them to brief exposures to ZD9331… CONTINUE READING


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