Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi.

@article{Lakshmi2010AntifilarialAI,
  title={Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi.},
  author={Vijai Lakshmi and Sujith Kurian Joseph and Shishir Kumar Srivastava and Shiv Kumar Verma and Malaya K. Sahoo and Val{\'e}rie Dub{\'e} and Sunil Kumar Mishra and Puvvada Kalpana Murthy},
  journal={Acta tropica},
  year={2010},
  volume={116 2},
  pages={127-33}
}
We evaluated the antifilarial activity of 6 flavonoids against the human lymphatic filarial parasite Brugia malayi using an in vitro motility assay with adult worms and microfilariae, a biochemical test for viability (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT)-reduction assay), and two animal models, Meriones unguiculatus (implanted adult worms) and Mastomys coucha (natural infections). In vitro, naringenin and hesperetin killed the adult worms and inhibited (>60%) MTT… CONTINUE READING
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