Antifibrotic role of inducible nitric oxide synthase.

@article{Ferrini2002AntifibroticRO,
  title={Antifibrotic role of inducible nitric oxide synthase.},
  author={M{\'o}nica G. Ferrini and Dolores Vernet and Thomas R. Magee and A Shahed and Ansha Qian and Jacob Rajfer and N{\'e}stor F. Gonz{\'a}lez-Cadavid},
  journal={Nitric oxide : biology and chemistry},
  year={2002},
  volume={6 3},
  pages={
          283-94
        }
}
Long-term treatment in rats with l-NAME, an isoform-non-specific inhibitor of nitric oxide synthase (NOS), leads to fibrosis of the heart and kidney, suggesting that nitric oxide (NO) may play a role in preventing tissue fibrosis. In this process, a likely target of NO is the quenching of reactive oxygen species (ROS) through peroxynitrite formation, and one possible source for this NO is inducible NOS (iNOS). Using Peyronie's disease (PD) tissue from both human specimens and from a rat model… CONTINUE READING

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