Antifibrotic properties of relaxin: in vivo mechanism of action in experimental renal tubulointerstitial fibrosis.

@article{Hewitson2010AntifibroticPO,
  title={Antifibrotic properties of relaxin: in vivo mechanism of action in experimental renal tubulointerstitial fibrosis.},
  author={Tim D. Hewitson and Wen Yang Ho and Chrishan S. Samuel},
  journal={Endocrinology},
  year={2010},
  volume={151 10},
  pages={4938-48}
}
This study examined the efficacy and in vivo mechanism of action of the antifibrotic hormone, relaxin, in a mouse model of unilateral ureteric obstruction (UUO). Kidney fibrosis was assessed in recombinant human gene-2 relaxin-treated animals maintained for 3 and 9 d after UUO. Results were compared with untreated and unoperated animals (d 0). Total… CONTINUE READING