Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats.

@article{Parsons2004AntifibroticEO,
  title={Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats.},
  author={Christopher J. Parsons and Blair U. Bradford and Clark Q Pan and Ellen N. Cheung and Michael W. Schauer and Andreas M. Knorr and Barbara H. Krebs and Sabine Kraft and Stefan Zahn and Bodo Brocks and Nikki M Feirt and Baisong Mei and M Cho and Roopa Ramamoorthi and Greg Roldan and Paul Ng and Peggy Lum and Claudia Hirth-Dietrich and Adrian Tomkinson and David Brenner},
  journal={Hepatology},
  year={2004},
  volume={40 5},
  pages={1106-15}
}
Liver fibrosis is characterized by increased synthesis, and decreased degradation, of extracellular matrix (ECM) within the injured tissue. Decreased ECM degradation results, in part, from increased expression of tissue inhibitor of metalloproteinase-1 (TIMP-1), which blocks matrix metalloproteinase (MMP) activity. TIMP-1 is also involved in promoting survival of activated hepatic stellate cells (HSCs), a major source of ECM. This study examined the effects of blocking TIMP-1 activity in a… CONTINUE READING

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