Antifibrotic effect through the regulation of transcription factor using ring type-Sp1 decoy oligodeoxynucleotide in carbon tetrachloride-induced liver fibrosis.

@article{Park2009AntifibroticET,
  title={Antifibrotic effect through the regulation of transcription factor using ring type-Sp1 decoy oligodeoxynucleotide in carbon tetrachloride-induced liver fibrosis.},
  author={Ji-hyun Park and Ji-Ho Jo and Kyung-hyun Kim and Soo-Jung Kim and Woo-Ram Lee and Kwan-Kyu Park and Jae-Bok Park},
  journal={The journal of gene medicine},
  year={2009},
  volume={11 9},
  pages={824-33}
}
BACKGROUND Liver fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM). Recent advances in the knowledge about the cellular, molecular and genetic aspects of fibrosis have opened a new era of research on liver cirrhosis. A transcription factor, Sp1, originally described as a ubiquitous transcription factor, is involved in the basal expression of ECM genes and may be important in the fibrotic processes. METHODS The chronic hepatic damage received intraperitoneal… CONTINUE READING