Antifibrotic and antioxidant effects of N-acetylcysteine in an experimental cholestatic model.

@article{GaliciaMoreno2012AntifibroticAA,
  title={Antifibrotic and antioxidant effects of N-acetylcysteine in an experimental cholestatic model.},
  author={Marina Galicia-Moreno and L. Favari and Pablo Muriel},
  journal={European journal of gastroenterology & hepatology},
  year={2012},
  volume={24 2},
  pages={179-85}
}
OBJECTIVES Several studies have suggested that oxidative stress may play an important role in the pathogenesis of hepatic injury during cholestasis in rats and humans. The aim of this study was to evaluate the ability of N-acetylcysteine (NAC) to prevent the damage induced by bile duct ligation (BDL) for 28 days in male Wistar rats. METHODS NAC was administered daily (300 mg/kg, orally) for 28 days. Alanine aminotransferase was quantified in the serum; lipid peroxidation, glutathione, and… CONTINUE READING
12 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…