Antifibrogenic effects of tamoxifen in a rat model of periportal hepatic fibrosis.


BACKGROUNDS/AIMS It has been reported that tamoxifen may affect hepatoma cell growth in vitro by suppressing transforming growth factor beta-1 (TGF-beta1) expression, suggesting that tamoxifen might also retard fibrogenesis. Thus, we examined whether tamoxifen might suppress TGF-beta1 expression and consequently inhibit the process of hepatic fibrosis in… (More)
DOI: 10.1111/j.1478-3231.2008.01811.x


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