Antifibrillatory properties of alinidine after coronary artery occlusion in rats.

@article{Harron1985AntifibrillatoryPO,
  title={Antifibrillatory properties of alinidine after coronary artery occlusion in rats.},
  author={Dean W. G. Harron and Maria Brezina and C. Lillie and Walter Kobinger},
  journal={European journal of pharmacology},
  year={1985},
  volume={110 3},
  pages={301-8}
}
Ligation of the left anterior descending coronary artery was performed in open-chest anaesthetized rats and mortality as well as changes in ECG were evaluated for 30 min thereafter. Saline or drugs were administered 15 min prior to ligation. In the control group, following a 4 min lag period ventricular arrhythmias as single ectopic beats, ventricular tachycardia and ventricular fibrillation (VF) appeared, reaching a maximum between 10 and 20 min and disappearing after 30 min. Mortality (40% in… CONTINUE READING