Antifertility Properties of the Hot Aqueous Extract of Guaiacum officinale

@article{Offiah2003AntifertilityPO,
  title={Antifertility Properties of the Hot Aqueous Extract of Guaiacum officinale},
  author={N. Offiah and C. Ezenwaka},
  journal={Pharmaceutical Biology},
  year={2003},
  volume={41},
  pages={454 - 457}
}
The hot aqueous extract of the aerial part (leaves, flowers, fruits and tender branches) of Guaiacum officinale Linn (Zygophyllaceae) was evaluated for antifertility effects. In over 50 trials, the extract caused abortion in mice and rats. The extract caused abortion in the second and third trimesters only. The abortion ED 50 in pregnant mice was 320.50 ± 20.00 mg/kg, while the LD 50 was 1280.13 ± 9.03 mg/kg. At a dose of 480.75 mg/kg, the extract significantly reduced the litter size in mice… Expand
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