Antifertility Action and Metabolism of Trimethylphosphate in Rodents

Abstract

RECENT studies with hexamethylphosphoramide (HMPA) and its analogues have shown that its antifertility activities in insects1 and rodents2 require the presence of all six methyl groups. Thus although pentamethylphosphoramide is a metabolite of HMPA in both the housefly3 and the rodent4 it does not possess significant antifertility activity in either species… (More)
DOI: 10.1038/220591a0

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