Antiestrogens increase protein tyrosine phosphatase activity in human breast cancer cells.

@article{Freiss1994AntiestrogensIP,
  title={Antiestrogens increase protein tyrosine phosphatase activity in human breast cancer cells.},
  author={Gilles Freiss and Françoise Vignon},
  journal={Molecular endocrinology},
  year={1994},
  volume={8 10},
  pages={1389-96}
}
Growth of human breast cancer cells is controlled by multiple interacting factors that trigger different intracellular signaling pathways. The nonsteroidal antagonist 4-hydroxytamoxifen (OH-Tam), which acts as an antiestrogen, is also able to inhibit the mitogenic activity of epidermal growth factor (EGF) on hormone-responsive MCF7 cells. To further characterize the mechanism of this antigrowth factor activity, which is accompanied by an increase of high-affinity EGF binding and a drastic… CONTINUE READING

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