Antiestrogens: structure-activity relationships and use in breast cancer treatment

@inproceedings{Traboulsi2016AntiestrogensSR,
  title={Antiestrogens: structure-activity relationships and use in breast cancer treatment},
  author={Tatiana Traboulsi and Mohamed El Ezzy and James L. Gleason and Sylvie Mader},
  booktitle={Journal of molecular endocrinology},
  year={2016}
}
About 70% of breast tumors express estrogen receptor alpha (ERα), which mediates the proliferative effects of estrogens on breast epithelial cells, and are candidates for treatment with antiestrogens, steroidal or non-steroidal molecules designed to compete with estrogens and antagonize ERs. The variable patterns of activity of antiestrogens (AEs) in estrogen target tissues and the lack of systematic cross-resistance between different types of molecules have provided evidence for different… CONTINUE READING
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