Antiestrogenic activity of vitamin A in in vivo uterotrophic assay.

@article{Koda2007AntiestrogenicAO,
  title={Antiestrogenic activity of vitamin A in in vivo uterotrophic assay.},
  author={Tomoko Koda and Hideki Imai and Masatoshi Morita},
  journal={Life sciences},
  year={2007},
  volume={80 10},
  pages={945-9}
}
All-trans-retinoic acid (ATRA), the primary active metabolite of vitamin A, was examined for its antiestrogenic activity in rats using an in vivo uterotrophic assay. All rats were ovariectomized 2 weeks prior to receiving 5 mg/kg/day ATRA or 0.3 micro g/kg/day ethynyl estradiol (EE) subcutaneously once a day for 3 consecutive days. Rats were sacrificed 1, 3… CONTINUE READING