Antiestrogenic Effects of All-fraws-Retinoic Acid and 1,25-Dihydroxyvitamin D3 in Breast Cancer Cells Occur at the Estrogen Response Element Level but through Different Molecular Mechanisms


Most breast tumors show estrogen-dependent growth and are thus susceptible to antiestrogenic therapy. MCF-7 cells, obtained from a human estrogen-dependent breast carcinoma, are widely used for studying the modulation of estrogenic responses by different effectors. All-/r<ms-retinoic acid (RA) and 1,25-dihydroxyvitamin I), (Vit I),i inhibited… (More)


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