Antiestrogen therapy is active in selected ovarian cancer cases: the use of letrozole in estrogen receptor-positive patients.

  title={Antiestrogen therapy is active in selected ovarian cancer cases: the use of letrozole in estrogen receptor-positive patients.},
  author={John F. Smyth and Charlie Gourley and Graeme Walker and Melanie J Mackean and Alan Stevenson and Alistair R W Williams and Awatif Al Nafussi and Tzyvia Rye and Ron Rye and Moira Stewart and Janet McCurdy and Max Senna Mano and Nick Simon Reed and Tracey V. McMahon and Paul A. Vasey and Hani Gabra and Simon P. Langdon},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={13 12},
PURPOSE To evaluate the efficacy of the aromatase inhibitor letrozole in preselected estrogen receptor (ER)-positive relapsed epithelial ovarian cancer patients and to identify markers that predict endocrine-sensitive disease. EXPERIMENTAL DESIGN This was a phase II study of letrozole 2.5 mg daily until clinical or marker evidence of disease progression in previously treated ER-positive ovarian cancer patients with a rising CA125 that had progressed according to Rustin's criteria. The primary… CONTINUE READING
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