Antiestrogen action in breast cancer cells: Modulation of proliferation and protein synthesis, and interaction with estrogen receptors and additional antiestrogen binding sites

@article{Katzenellenbogen1985AntiestrogenAI,
  title={Antiestrogen action in breast cancer cells: Modulation of proliferation and protein synthesis, and interaction with estrogen receptors and additional antiestrogen binding sites},
  author={Benita S Katzenellenbogen and Margaret Ann Miller and Alaka Mullick and Yhun Yhong Sheen},
  journal={Breast Cancer Research and Treatment},
  year={1985},
  volume={5},
  pages={231-243}
}
Antiestrogens have proven to be effective in controlling the growth of hormone-responsive breast cancers. At the concentrations of antiestrogens achieved in the blood of breast cancer patients taking antiestrogens (up to 2 × 10−6 M), antiestrogens selectively inhibit the proliferation of estrogen receptor-containing breast cancer cells, and this inhibition is reversible by estradiol. Antiestrogens also inhibit estrogen-stimulation of several specific protein synthetic activities in breast… CONTINUE READING