Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy.

@article{Lscher1998AntiepileptogenicEO,
  title={Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy.},
  author={W L{\"o}scher and Dagmar H{\"o}nack and Chris Rundfeldt},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={284 2},
  pages={474-9}
}
We have previously shown that the novel anticonvulsant levetiracetam exerts potent anticonvulsant activity against both focal and secondarily generalized seizures in fully amygdala-kindled rats, i.e. , a model of temporal lobe epilepsy. We examined whether levetiracetam also exhibits antiepileptogenic activity, i.e., prevents or retards acquisition or development of amygdala-kindling in rats. Before the experiments with chronic administration of levetiracetam at different doses, we determined… CONTINUE READING
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Levetiracetam (ucb L059) prevents limbic seizures induced by pilocarpine and kainic acid in rats

  • H Klitgaard, A Matagne, J Gobert, E Wülfert
  • Epilepsia 37(Suppl
  • 1996
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