Antiepileptic therapy in patients with central nervous system malignancies

  title={Antiepileptic therapy in patients with central nervous system malignancies},
  author={Glen H.J. Stevens},
  journal={Current Neurology and Neuroscience Reports},
  • G. Stevens
  • Published 1 July 2006
  • Medicine
  • Current Neurology and Neuroscience Reports
More than 200,000 patients are diagnosed with primary or metastatic brain tumors each year in the United States. Of these patients, 20% to 40% will develop seizures at presentation, and another 20% to 40% will require treatment for seizures during their illness. Although the use of antiepileptic drugs (AEDs) in patients who have had seizures seems reasonable, the issue of prophylactic AED use for patients who have not had a seizure is an intensely debated subject. The American Academy of… 
The Management of Seizures in Brain Tumor Patients
  • Kristen Smith
  • Medicine, Psychology
    The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses
  • 2010
Since the 1990s, newer antiepileptic drugs, which have fewer drug interactions, have been introduced and show promise as first-line therapy and adjunct treatment of epilepsy.
Antiepileptic treatment in paediatric oncology--an interdisciplinary challenge.
Clinicians will need to continue to question current policies and adapt their daily practice to evolving scientific data to avoid unnecessary long-term antiepileptic drug (AED) treatment.
Epileptic Seizures and Supratentorial Brain Tumors in Children
Brain tumors represent about one third of the pediatric tumors and are in a relevant percentage of cases the cause of a drug-resistant epilepsy, that can be successfully treated by surgery.
Head's up on the treatment of malignant glioma patients.
This article will provide an update and review of the care and treatment of patients with the most common type of tumor, glial malignancies, and investigates the association between exposure to extremely low-frequency electromagnetic fields and the development of a primary brain tumor.
Pediatric brain tumors and epilepsy.
Dying of brain tumours: specific aspects of care
Data suggest that patients with primary or metastatic brain tumours often have a high symptom burden and unmet needs for palliative care, and symptoms are hard to diagnose; patients suffer often and early from cognitive impairment but are rarely appropriately prepared concerning end-of-life wishes.
Evaluation of The Efficacy of Pregabalin in Oncology Patients With Neuropathic Pain
Pregabalin that has been frequently used in recent years for neuropathic pain in the practice of different clinics, was found to be highly effective both in short-term and mid-term in oncology patients.
Supportive care in neurooncology.


Seizure prophylaxis in patients with brain tumors: a meta-analysis.
No evidence supports AED prophylaxis with phenobarbital, phenytoin, or valproic acid in patients with brain tumors and no history of seizures, regardless of neoplastic type.
Practice parameter: Anticonvulsant prophylaxis in patients with newly diagnosed brain tumors
The Quality Standards Subcommittee seeks to develop scientifically sound, clinically relevant practice parameters for the practice of neurology with a focus on anticonvulsants in patients with primary and metastatic brain tumors.
Medical management of patients with brain tumors
There is increasing evidence that brain tumor patients who have not had a seizure do not benefit from prophylactic antiepileptic medications, and low-molecular weight heparin may be more effective than coumadin.
Add-on Gabapentin for Refractory Seizures in Patients With Brain Tumours
  • J. Perry, C. Sawka
  • Medicine
    Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
  • 1996
Gabapentin was well tolerated in patients with brain tumours and efficacy persisted over time, suggesting that this novel mechanism of action may have been enhanced in patients due to the abnormal blood-brain barrier associated with cerebral tumours.
Treating seizures in patients with brain tumors: Drug interactions between antiepileptic and chemotherapeutic agents.
The potential interactions between AEDs and chemotherapy should be anticipated and appropriate proactive adjustments implemented, and gabapentin and levetiracetam show the most promise in treating epileptic seizures in patients with brain tumors.
Medical management of patients with brain tumors.
There is increasing evidence that brain tumor patients who have not had a seizure do not benefit from prophylactic antiepileptic medications and that the risk of hemorrhage with anticoagulation is relatively small.
Phase I clinical and pharmacokinetic study of irinotecan in adults with recurrent malignant glioma.
  • M. Gilbert, J. Supko, S. Grossman
  • Medicine, Biology
    Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2003
It is confirmed that the concomitant administration of EIAs results in marked enhancement in the CL of irinotecan, and the importance of assessing the potential for pharmacokinetic interactions between concurrent medications and chemotherapeutic agents is underscored.
Alternative therapy use in neurologic diseases
Alternative therapy use in brain tumor patients is common and may reflect unmet patient needs with respect to their cancer care within the current model of health care delivery.
Effect of cranial irradiation on seizure frequency in adults with low‐grade astrocytoma and medically intractable epilepsy
Iradiation can reduce seizure frequency in some patients with unresected cerebral hemisphere low-grade astrocytoma and medically intractable epilepsy.
Factors influencing seizures in adult patients with supratentorial astrocytic tumors
The patients with preoperative seizures had a higher risk of postoperative seizures and should be carefully monitored, and imaging examination of brain to exclude the possibilities of tumor recurrence or hemorrhage is warrantable in supratentorial astrocytoma patients with postoperative seizure.