Antiepileptic effects of botulinum neurotoxin E.

  title={Antiepileptic effects of botulinum neurotoxin E.},
  author={Laura Costantin and Yuri Bozzi and Cristina Richichi and Alessandro Viegi and Flavia Antonucci and Marcella Funicello and Marco Gobbi and Tiziana Mennini and Ornella Rossetto and Cesare Montecucco and Lamberto Maffei and Annamaria Vezzani and Matteo Caleo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={25 8},
Experimental studies suggest that the delivery of antiepileptic agents into the seizure focus might be of potential utility for the treatment of focal-onset epilepsies. Botulinum neurotoxin E (BoNT/E) causes a prolonged inhibition of neurotransmitter release after its specific cleavage of the synaptic protein synaptosomal-associated protein of 25 kDa (SNAP-25). Here, we show that BoNT/E injected into the rat hippocampus inhibits glutamate release and blocks spike activity of pyramidal neurons… CONTINUE READING


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Interleukin-1 immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures

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