Antiepileptic drugs interact with folate and vitamin B12 serum levels

@article{Linnebank2011AntiepilepticDI,
  title={Antiepileptic drugs interact with folate and vitamin B12 serum levels},
  author={M. Linnebank and S. Moskau and A. Semmler and G. Widman and B. Stoffel‐Wagner and M. Weller and C. Elger},
  journal={Annals of Neurology},
  year={2011},
  volume={69}
}
OBJECTIVE Antiepileptic drugs (AEDs) are important for the treatment of epilepsy, psychiatric diseases, and pain syndromes. [...] Key Method A total of 2730 AED-treated and 170 untreated patients with epilepsy and 200 healthy individuals were enrolled. Expand

Paper Mentions

Interventional Clinical Trial
The present study is planned to study effect of folic acid supplementation on homocysteine levels and CV risk factors such as BP and lipids in adolescent epileptics taking anti… Expand
ConditionsEpilepsy
InterventionDrug
Antiepileptic drugs and vitamin B6 plasma levels in adult patients
TLDR
Analysis of vitamin B6 blood levels in 400 serial patients with epilepsy, AED-treated, untreated, untreated and healthy controls shows no support for the hypothesis that vitamin B 6 blood levels are influenced by AED treatment. Expand
Drug-Induced Megaloblastic Anemia.
Many common drugs induce megaloblastic anemia by interfering with folate or vitamin B12 absorption, altering B12 metabolism, or blocking pathways in which these vitamins play a role. Supplements toExpand
Phenytoin-Folate Interactions: How Far is Safe Folate Supplementation in Phenytoin Treated Epileptic Patients?
TLDR
The feasibility of using folate supplements to avoid such inadvertent drug sequelae in epileptic patients kept on chronic treatment with phenytoin is discussed. Expand
Management of antiepileptic drug–induced nutrition-related adverse effects
TLDR
The adverse effects of AEDs on some of the nutrition-related issues, including bone health, body weight, glucose and lipid metabolism, vitamin homeostasis, antioxidant defense system, and pregnancy are reviewed. Expand
B-Vitamin deficiency in patients treated with antiepileptic drugs
TLDR
It is demonstrated that treatment with inducing AEDs commonly causes pyridoxine deficiency, often severe, which could conceivably contribute to the polyneuropathy sometimes attributed to older Aeds, as well as other chronic heath difficulties. Expand
Effects of antiepileptic drugs on the serum folate and vitamin B12 in various epileptic patients
TLDR
Various AEDs may decrease the serum levels of folate and vitamin B12 and affect the secondary cerebrovascular events in various epileptic patients, and regular supplementation of folates and vitaminB12 may be an option. Expand
Antiepileptic drugs, hyperhomocysteinemia and B-vitamins supplementation in patients with epilepsy
TLDR
The latest findings on the role of supra-physiological tHcy concentrations as vascular risk factor in patients with epilepsy are reviewed and the possible role played by folate and other B-vitamins supplementation in epileptic patient with hyper-tHcy is discussed. Expand
Analysis of carbamazepine side effects associated with bone metabolism, folate and vitamin B12 serum levels in Isfahan epileptic patients
TLDR
Investigation of carbamazepine effects on bone density, serum levels of folate, vitamin B12 and other biochemical variables in adult epileptic patients who received CBZ for treatment of epileptic attacks found no correlation between CBZC 0 and homocysteine levels, and further studies related to efficacy and side-effects of CBZ as the most prescribed AEDs in Iranian epileptic population seem to be valuable. Expand
Vitamin B12 deficiency: an unusual cause for recurrent generalised seizures with pancytopaenia
TLDR
Seizures are an unusual manifestation of vitamin B12 deficiency and possible mechanisms of epileptogenesis are discussed. Expand
Enzyme induction with antiepileptic drugs: Cause for concern?
TLDR
Induction of enzyme‐inducing AEDs may contribute to the development of a number of comorbidities, including osteoporosis, sexual dysfunction, and vascular disease, and perhaps consideration should be given to starting treatment with, or even switching patients to, non–enzyme‐inducingAEDs. Expand
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TLDR
The aim of the present study was to investigate the effect of new AEDs on plasma tHcy levels, and older enzyme‐inducing antiepileptic drugs may induce supraphysiologic plasma concentrations of total homocysteine. Expand
Long‐term antiepileptic drug therapy contributes to the acceleration of atherosclerosis
TLDR
The hypothesis that the cumulative effect of long‐term exposure to AEDs plays a pivotal role in the pathogenesis of atherosclerosis in patients with epilepsy is evaluated. Expand
Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, Vitamin B12, folic acid and Vitamin B6
TLDR
It is suggested that increase of homocysteine levels may be due to anti-epileptic drug use, rather than being epileptic in origin, and changes observed are not related to the alteration in the levels of cofactors and remain unclear in the patients using valproic acid. Expand
Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy
TLDR
This study showed an early effect of antiepileptic drug treatment on homocysteine metabolism in epileptic children before and after a 20-week period of sodium valproate and carbamazepine monotherapy. Expand
Anti-epileptic drug treatment in children: hyperhomocysteinaemia, B-vitamins and the 677C-->T mutation of the methylenetetrahydrofolate reductase gene.
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  • Medicine
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TLDR
The lowering action of carbamazepine treatment on folate levels seems to be associated with hyperhomocysteinaemia, which appears to be related to the homozygous condition for the MTHFR 677C-->T mutation. Expand
Hyperhomocysteinemia in patients with epilepsy: Does it play a role in the pathogenesis of brain atrophy? A preliminary report
TLDR
Investigation of the possible association of hyper‐tHcy with BA in a population of patients with epilepsy found no link with brain atrophy. Expand
Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid
TLDR
FA may be added to the treatment protocol for patients taking these antiepileptic drugs to decrease the degenerative effect of VA and CBZ on vascular endothelium. Expand
Blood homocysteine, folate and Vitamin B-12 concentrations in patients with epilepsy receiving lamotrigine or sodium valproate for initial monotherapy
TLDR
The data indicate that hyperhomocysteinemia may not be a serious clinical problem among patients with epilepsy, who receive either LTG or VPA. Expand
Second-generation antiepileptic drugs' impact on balance: a meta-analysis.
TLDR
Second-generation AEDs at standard dosages, except for gabapentin and levetiracetam, increase the imbalance risk, and evidence exists for a dose-response effect. Expand
Cognitive side-effects of chronic antiepileptic drug treatment: A review of 25 years of research
TLDR
There is little reason to recommend any of the first-line AEDs as the AED of choice from the standpoint of cognitive side-effects, and the tentative overall picture emerging from the creme de la creme of research on cognitive AED effects is that differences in cognitive profiles may not be very large. Expand
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