Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.

@article{Lindhout1992AntiepilepticDA,
  title={Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.},
  author={Dick Lindhout and H. Meinardi and Jan Willem Meijer and Heinz Nau},
  journal={Neurology},
  year={1992},
  volume={42 4 Suppl 5},
  pages={94-110}
}
We analyzed the influence of changes in the prescribing of antiepileptic drugs to pregnant women on frequency and pattern of malformations in their offspring by comparing two consecutive cohorts (1972 to 1979, cohort A; 1980 to 1985, cohort B). In cohort A, 15 (10%) of 151 exposed, live-born infants had one or more congenital anomalies, which consisted primarily of congenital heart defects, facial clefts, and syndromes of dysmorphia with developmental retardation, in association with… CONTINUE READING

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