Antiepileptic drugs and brain maturation: fetal exposure to lamotrigine generates cortical malformations in rats.

@article{Manent2008AntiepilepticDA,
  title={Antiepileptic drugs and brain maturation: fetal exposure to lamotrigine generates cortical malformations in rats.},
  author={J P Manent and Isabel Jorquera and Valentina Franco and Yehezkel Ben-Ari and Emilio Perucca and Alfonso Represa},
  journal={Epilepsy research},
  year={2008},
  volume={78 2-3},
  pages={131-9}
}
Intake of antiepileptic drugs (AEDs) during pregnancy can provoke severe and subtle fetal malformations associated with deleterious sequelae, reflecting the need for experimental investigations on the comparative teratogenic potential of these agents. We recently reported that prenatal exposure to vigabatrin and valproate, two AEDs which act through GABAergic mechanisms, induces hippocampal and cortical dysplasias in rodents. We have now investigated the effects of phenobarbital (PB, 30 mg/kg… CONTINUE READING
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