Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.

@article{Citraro2013AntiepilepticAO,
  title={Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.},
  author={R. Citraro and Emilio Russo and Francesca Scicchitano and Clementina M. van Rijn and Donato Cosco and Carmen Avagliano and Roberto Russo and Giuseppe D'Agostino and Stefania Petrosino and Francesca Guida and Luisa Gatta and Gilles L J M van Luijtelaar and Sabatino Maione and Vincenzo Di Marzo and Antonio Calignano and Giovambattista De Sarro},
  journal={Neuropharmacology},
  year={2013},
  volume={69},
  pages={115-26}
}
N-palmitoylethanolamine (PEA), an endogenous fatty acid ethanolamide, plays a key role in the regulation of the inflammatory response and pain through, among others, activation of nuclear peroxisome proliferator-activated receptors (PPAR-α). Endogenous cannabinoids play a protective role in several central nervous system (CNS) disorders, particularly those associated with neuronal hyperexcitability. We investigated the effects of PEA and the role of PPAR-α in absence epilepsy using the WAG/Rij… CONTINUE READING