Antiendotoxin activity of antimicrobial peptides and glycopeptides.

@article{Giacometti2003AntiendotoxinAO,
  title={Antiendotoxin activity of antimicrobial peptides and glycopeptides.},
  author={Andrea Giacometti and Oscar Cirioni and Roberto Ghiselli and Fiorenza Orlando and Federico Mocchegiani and Giuseppina D'Amato and C. A. Di Silvestri and Alessandra Riva and Maria Simona Del Prete and Vittorio Saba and Giorgio Scalise},
  journal={Journal of chemotherapy},
  year={2003},
  volume={15 2},
  pages={129-33}
}
An animal study was performed to investigate the efficacy of two glycopeptides and two cationic peptides in the prevention of lethality in a septic shock rat model. Adult Wistar rats were given an intraperitoneal injection of 2x10(10) CFU of Escherichia coli ATCC 25922, with the exception of an uninfected control group (C0). Animals were randomized to receive, immediately after bacterial challenge, intraperitoneally isotonic sodium chloride solution (control group C1), 3 mg/Kg teicoplanin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-5 of 5 extracted citations

Pharmacokinetics and pharmacodynamics of 'old' polymyxins: what is new?

Diagnostic microbiology and infectious disease • 2012
View 2 Excerpts
Highly Influenced

Colistin monotherapy vs. combination therapy: evidence from microbiological, animal and clinical studies.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases • 2008
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…